PN is a chronic neuroimmune skin condition1
- PN has the highest itch intensity among the many types of chronic pruritus1
- This itch can be associated with multiple sensations, such as stinging, prickling, burning, and pain2
The intense itch of PN is the most burdensome symptom for patients3
reported itch as their top
complaint to their doctor3
rated itch as their
worst symptom4
reported itch as a direct
cause of sleep disturbance4
What is driving the itch and scratching of PN?
Complex neuroimmune interactions contribute to the pathophysiology of PN1,5
Itch signals transmitted to the central nervous system from the skin are enhanced by elongation and branching of sensory neurons1,5
Cytokines released by immmune cells and impaired keratinocyte differentiation amplify itch1,5
The role of IL-31 in itch and more5-11
Unlike other cytokines, IL-31 has emerged as a key neuroimmune cytokine and a direct driver of:
- ITCH
- INFLAMMATION
- skin barrier DYSFUNCTION
- FIBROSIS
Fast Itch Relief
See how NEMLUVIO significantly improved itch in both pivotal and long-term studies12
Unique Mechanism of Action
NEMLUVIO is the first treatment to target IL‑31RA, a key neuroimmune driver of itch and more to disrupt PN11,13
Sign up now for more information about NEMLUVIO and PN
IL-31=interleukin 31; PN=prurigo nodularis.
References: 1. Williams KA, Roh YS, Brown I, et al. Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis. Expert Rev Clin Pharmacol. 2021;14(1):67-77. doi:10.1080/17512433.2021.1852080 2. Kwatra SG, Yosipovitch G, Legat FJ, et al. Phase 3 trial of nemolizumab in patients with prurigo nodularis. N Engl J Med. 2023;389:1579-1589. doi:10.1056/NEJMoa2301333 3. Pereira MP, Basta S, Moore J, Ständer S. Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need. J Eur Acad Dermatol Venereol. 2018;32:2224-2229. doi:10.1111/jdv.15107 4. Rodriguez D, Kwatra SG, Dias-Barbosa C, et al. Patient perspectives on living with severe prurigo nodularis. JAMA Dermatol. 2023;159(11):1205–1212. doi:10.1001/jamadermatol.2023.3251 5. Hänel KH, Pfaff CM, Cornelissen C, et al. Control of the physical and antimicrobial skin barrier by an IL-31-IL-1 signaling network. J Immunol. 2016;196(8):3233-3244. doi:10.4049/jimmunol.1402943 6. Bewley A, Homey B, Pink A. Prurigo nodularis: a review of IL-31RA blockade and other potential treatments. Dermatol Ther (Heidelb). 2022;12(9):2039-2048. doi:10.1007/13555-022-00782-2 7. Gibbs BF, Patsinakidis N, Raap U. Role of the pruritic cytokine IL-31 in autoimmune skin diseases. Front Immunol. 2019;10:1383. doi:10.3389/fimmu.2019.01383 8. Mousa A, Bakhiet M. Role of cytokine signaling during nervous system development. Int J Mol Sci. 2013;14(7):13931-13957. doi:10.3390/ijms140713931 9. Feld M, Garcia R, Buddenkotte J, et al. The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves. J Allergy Clin Immunol. 2016;138(2):500-508.e24. doi:10.1016/j.jaci.2016.02.020 10. Dubin C, Del Duca E, Guttman-Yassky E. The IL-4, IL-13 and IL-31 pathways in atopic dermatitis. Expert Rev Clin Immunol. 2021;17(8):835-852. doi:10.1080/1744666X.2021.1940962 11. DUPIXENT. Prescribing information. Sanofi Genzyme; 2023. 12. Galderma Laboratories, L.P.; data on file. 13. NEMLUVIO (nemolizumab-ilto) injection 30 mg Prescribing Information. Dallas, TX: Galderma Laboratories, L.P.; August 2024.